The Myc/Max/Mad network of transcription factors regulates many cellular functions, including proliferation, differentiation, and apoptosis. This network comprises the Myc family of nuclear proto-oncoproteins (c-, N-, and L-Myc), Max, and the Mad family of proteins (Mad1, Mxi1, Mad3, Mad4, and Mnt/Rox). These proteins are a subgroup of basic helix-loop-helix leucine zipper (bHLHZIP) family transcription regulators and can form dimers in multiple combinations through interactions mediated by the helix-loop-helix leucine zipper dimerization interface. Different members of the Myc/Max/Mad family have distinct biological functions; Myc proteins promote cell proliferation, whereas Mad family proteins limit proliferation. Different members of the Myc/Max/Mad family have distinct biological functions; Myc proteins promote cell proliferation, whereas Mad family proteins limit proliferation. The balance between Myc and Mad family proteins is an important determinant of cell proliferation. Myc and Mad family proteins form dimers with Max, and dimerization with Max is essential for the regulatory functions of Myc and Mad family proteins. Members of the Myc and Mad families are generally not able to form homodimers or heterodimers with each other. Here you can see the structure of the structure of Mad-Max in complex with a synthetic DNA target (PDB code: 1NLW)
#molecularart ... #immolecular ... #mad-max ... #transcription ... #proliferation ... #cycle ... #cancer ... #myc ... #DNA ... #promoter ... #xray
Structure of the protein-DNA complex rendered with @proteinimaging and depicted with @corelphotopaint
#molecularart ... #immolecular ... #mad-max ... #transcription ... #proliferation ... #cycle ... #cancer ... #myc ... #DNA ... #promoter ... #xray
Structure of the protein-DNA complex rendered with @proteinimaging and depicted with @corelphotopaint
